How It Works
Hydration fades.
A rebuilt matrix doesn't.
The Mechanism
Re2O delivers a purified, human tissue-derived extracellular matrix (ECM) directly into the mid-dermis — the same structural layer where your skin's own collagen, elastin, and hyaluronic acid naturally reside. Rather than simply adding volume or moisture, it supplies the biological scaffolding your skin uses to rebuild itself, integrating into tissue your body already recognizes as its own.
Once in place, the matrix acts as a framework for your own fibroblasts, which populate it and gradually lay down fresh collagen over the following weeks. The result is a slow, structural renewal that doesn't peak overnight — it rebuilds quietly, from within.
The Procedure Essentials
PROCEDURE TIME
20–30 minutes
ANESTHESIA
Topical numbing cream
DOWNTIME
Minimal — redness 24–48 hours, mild swelling 1–3 days
WHEN RESULTS APPEAR
Initial texture change 2–4 weeks; peak results at 3–4 months
HOW LONG RESULTS LAST
9–12 months typical, up to 18 months with the full protocol
RECOMMENDED FREQUENCY
Initial course of 2–3 sessions (4–8 weeks apart) for full results, or a single higher-dose session for one-time visitors
PROCEDURE TIME | 20–30 minutes |
ANESTHESIA | Topical numbing cream |
DOWNTIME | Minimal — light redness/swelling for 1–2 days |
RECOMMENDED FREQUENCY | Initial course of 2–3 sessions (4–8 weeks apart) for full results, or a single higher-dose session for one-time visitors |
WHEN RESULTS APPEAR | Gradual lift over 2–3 months as new collagen forms |
HOW LONG RESULTS LAST | Typically 12–18 months, varying by individual |
WHERE IT WORKS
Best Targeted Areas
Re2O delivers the most visible results in four specific zones — each requiring a tailored injection depth and formulation that Dr. Kang adjusts to the individual, session by session.
01
Brow & Forehead
Lifts a heavy or drooping brow line to open up the eye area — one of the most requested treatments among our international patients.
02
Jawline & Lower Face
Tightens and defines a softened jawline, reducing early jowl formation for a sharper, more sculpted profile.
03
Under-Chin & Submental Area
Firms loose skin under the chin without surgery — especially effective when combined with LALICut fat dissolving for a complete contouring result.
04
Neck & Décolletage
Smooths horizontal neck lines and improves skin laxity on the chest — often overlooked areas that reveal age early.
01
UNDER-EYE
Softens fine lines and dark circles around the delicate under-eye area, where thin skin and dense nerve structure call for a lighter, more careful injection technique.
02
CHEEK
Rebuilds structural density and elasticity in the cheeks, improving pore appearance and restoring a fuller, more supported contour.
03
NASOLABIAL FOLDS
Softens nasolabial folds without surgery or filler, restoring firmness to skin that has lost structural support with age.
04
NECK
Improves neck wrinkles and sagging skin, restoring density in an area where the skin is thinner and ages faster than the face.
THE LALIAN DIFFERENCE
Why Lalian for Re20
Every Session, Led by Dr. Kang
At many clinics, skin boosters are delegated to nurses or technicians. At Lalian, every injection is administered personally by Dr. Jiyoun Kang, with over 12 years of experience in non-surgical aesthetic treatments. She adjusts injection depth, dosage, and placement in real time based on your skin's condition — not a preset protocol.
02
3D MetaView Skin Analysis Before Every Treatment
Lalian does not sell Ultherapy by shot count. We design each session by tissue response — placing energy where your skin needs it, skipping where it doesn't. Fewer unnecessary shots means less discomfort and better results.
Before your session begins, Dr. Kang conducts a full 3D MetaView assessment to map your facial structure, skin thickness, and areas of laxity. This is how your protocol becomes yours — not a standard fixed-dose package applied identically to every patient.
03
Precision Over Volume
Lalian does not sell Re2O by a fixed cc package. We design each session by skin condition — placing the matrix where your skin needs it, skipping where it doesn't. Less unnecessary product means less discomfort and better results.
01
THE LALIAN DIFFERENCE
COMBINATION CARE
Synergy Protocols
PROTOCOL 01
Re2O + Ultherapy Prime
Combine Ultherapy Prime's structural lifting (SMAS layer) with Re2O's dermal matrix rebuilding (mid-dermis) — two different depths, addressing laxity and thinning together. The order matters: heat-based lifting is done first, and Re2O is injected only once the treated area has stabilized.
PROTOCOL 02
Re2O + Thermage FLX
Combine Thermage FLX's radiofrequency tightening with Re2O's dermal matrix rebuilding — the same sequencing principle applies: RF tightening first, then Re2O injected once the treated area has stabilized.
PROTOCOL 03
Re2O + Rejuran or Juvelook
Re2O integrates well alongside HA-based skin boosters. For patients already on a Rejuran or Juvelook schedule, Re2O can complement rather than duplicate the existing routine.
COMBINATION CARE
COMMON QUESTIONS
FAQ — Re20
at Lalian Cheongdam
Re2O is a purified, human tissue-derived extracellular matrix (ECM). The material is processed to remove cellular components that can trigger immune responses, so it integrates into the skin's own dermal structure with minimal rejection risk.
Rejuran uses salmon-derived PN, Juvelook is a synthetic PDLLA biostimulator, and Re2O is a human tissue-derived matrix — each supports skin regeneration through a different mechanism. This is also why duration differs: Rejuran typically lasts 3–6 months and Juvelook 6–12 months, while Re2O's structural matrix tends to last 9–12 months.
Most patients report mild discomfort managed with topical numbing; sensation is comparable to other injectable skin boosters.
Most patients complete an initial course of 2–3 sessions, spaced 4–8 weeks apart, followed by an annual maintenance session.
Results typically last 9–12 months, with some patients reporting benefits for up to 18 months with the full protocol.
Yes — Re2O is designed to show visible improvement after a single, fuller-dose session, making it practical for one-time visitors. For patients who can return to Seoul, a 2–3 session course spaced 4–8 weeks apart builds a more complete, longer-lasting result — but a single well-dosed session is a legitimate option on its own.
COMMON QUESTIONS
What to Expect:
REAL PATIENT PROGRESS
Every face responds differently. These images show actual patient outcomes following Re2O treatments at Lalian Cheongdam — photographed under standardized clinical conditions by Dr. Kang's team. Individual results vary depending on skin condition, age, and treatment protocol.
Re2O is a human tissue-derived ECM (extracellular matrix) and PN skin booster that restores the dermal scaffold beneath the skin — not just hydration on top of it. At Lalian Cheongdam, every session is personally assessed and administered by Dr. Jiyoun Kang.
Re2O · hADM Matrix · Injectable Skin Regeneration
Re2O · hADM Matrix · Injectable Skin Regeneration
Re2O in Seoul
Deep Dermal Regeneration at Lalian Cheongdam
Re2O is a human tissue-derived ECM (extracellular matrix) skin booster that restores the dermal scaffold beneath the skin — not just hydration on top of it. At Lalian Cheongdam, every session is personally assessed and administered by Dr. Jiyoun Kang.
PROCEDURE20–30 minutes
DOWNTIME
Minimal
RESULTS LAST
9-12 months
PROCEDURE
45~90 min
DOWNTIME
Minial
RESULTS LAST
Up to 2 years
